Unveiling Primary Aldosteronism in the Absence of Adrenal Morphological Abnormalities: A Case Report in a Hypertensive Female

A Case Report | Open Access

Volume 2025 - 4 | Article ID 274 | http://dx.doi.org/10.51521/WJCRCI.2025.e42.419

Unveiling Primary Aldosteronism in the Absence of Adrenal Morphological Abnormalities: A Case Report in a Hypertensive Female

Academic Editor: John Bose

Received 2025-09-30
Revised 2025-10-15
Accepted 2025-10-20
Published 2025-10-31

^1,2Ikram Tahani, M.D, ^1,2Yasmine Ouaddouh, M.D, ^1,2Soumia Boulouiz, M.D, ^1,2,3Zakaria Bazid, M.D, PhD, ^1,2,3Noha El Ouafi, M.D, PhD, ^1,2,3Nabila Ismaili, M.D

¹Faculty of Medicine and Pharmacy, Mohammed I^st University, Oujda, Morocco

²Department of Cardiology, Mohammed VI University Hospital/Mohammed I University Oujda Morocco.

³Laboratory of Epidemiology, Clinical Research and Public Health, Faculty of Medicine and Pharmacy, Oujda, Morocco

^1,2Ikram Tahani, M.D, Email: ikramtahani1@gmail.com

^1,2Yasmine Ouaddouh, M.D, Email: yasmine.ouadd@gmail.com

^1,2Soumia Boulouiz, M.D, Email: soumia.boulouiz@gmail.com

^1,2,3Zakaria Bazid, M.D, PhD, Email: bazidzakaria@gmail.com

^1,2,3Noha El Ouafi, M.D, PhD, Email: Pr.elouafi@gmail.com

^1,2,3Nabila Ismaili, M.D, PhD, Email: Ismaili.nabilette@yahou.com

Corresponding Author: Ikram Tahani, BD BRAHIM ROUDANI LOT ENNAKHIL H 04 NR 34 , Oujda, Morocco, Email: ikramtahani1@gmail.com

Citation: Ikram Tahani, Yasmine Ouaddouh, Soumia Boulouiz, Zakaria Bazid, Noha El Ouafi, Nabila Ismaili (2025) Unveiling Primary Aldosteronism in the Absence of Adrenal Morphological Abnormalities: A Case Report in a Hypertensive Female. World J Case Rep Clin Imag. 2025 October; 4(2)1-5.

Copyrights: © Ikram Tahani, et al., 2025, This article is licensed under the Creative Commons Attribution-Non Commercial-4.0-International-License-(CCBY-NC) (https://worldjournalofcasereports.org/blogpage/copyright-policy). Usage and distribution for commercial purposes require written permission.

Abstract:

Primary aldosteronism [PA] represents a well-recognized etiology of secondary hypertension, most commonly attributed to aldosterone-producing adenomas and bilateral adrenal hyperplasia, which together account for over 95% of documented cases. Less frequently, PA may arise from adrenal carcinoma or hereditary forms such as familial hyperaldosteronism. In recent years, however, an expanding subset of patients has been described in whom standard imaging fails to reveal discernible adrenal abnormalities, thereby complicating disease subtyping and therapeutic decision-making. Such atypical presentations pose considerable diagnostic challenges and often require advanced investigations to guide optimal management. Here, we report the case of a 45-year-old hypertensive woman with a history of migraine, whose adrenal MRI appeared unremarkable despite biochemical evidence strongly suggestive of PA.

Keywords: Primary aldosteronism, Adrenal imaging, Normal adrenal MRI, Secondary hypertension, Atypical presentation.