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World Journal of Case Reports and Clinical Images
World Journal of Case Reports and Clinical Images
Academic Editor: John Bose
Dr. David Ikudayisi, Dr. Darlington Amadi, Dr. Olalekan
Kolawole
Glory
Wellness & Regenerative Centre, Lagos, Nigeria.
Corresponding Author & Copyrights: Dr. David Ikudayisi, Glory Wellness & Regenerative Centre, Block 78 Plot 14B, Dan
Ogbeide Close, Lekki Phase 1, Lekki, Lagos, Nigeria. Email:
glorywellness@outlook.com
Citation: Dr. David Ikudayisi, Dr. Darlington
Amadi, Dr. Olalekan Kolawole (2026) Intravenous Umbilical Cord Mesenchymal Stem
Cell Therapy in Pediatric Alopecia Areata: A Case Report. World J Case Rep Clin
Imag. 2026 August; 5(2),1-7.
Copyrights © Dr. David Ikudayisi, et al., 2026,
This article is licensed under the Creative Commons Attribution-Non
Commercial-4.0-International-License-(CCBY-NC)
(https://worldjournalofcasereports.org/blogpage/copyright-policy). Usage and
distribution for commercial purposes require written permission.
Abstract:
Objective: To describe the clinical
outcome of intravenous umbilical cord–derived mesenchymal stem cell (UC-MSC)
therapy in a 10-year-old male with treatment-resistant alopecia areata. Methods:
A 10-year-old male with a two-year history of relapsing alopecia areata
unresponsive to standard therapies received two intravenous UC-MSC infusions at
9 months apart, and the improvement documented is over a period of 16 months.
Clinical assessment included serial scalp photography, Severity of Alopecia
Tool (SALT) scoring, and routine laboratory monitoring. Results: Progressive
and sustained hair regrowth was observed. The SALT score improved from 52 at
baseline to 10 at final follow-up. Perifollicular erythema resolved after the
initial infusion. No infusion-related adverse events or systemic complications
were recorded. Conclusion: Intravenous UC-MSC therapy was well tolerated
and associated with marked clinical improvement in this pediatric case of refractory
alopecia areata. While spontaneous remission cannot be excluded, the temporal
relationship between treatment and response supports further investigation of
systemic MSC therapy in pediatric autoimmune hair loss.
Keywords: Alopecia Areata, Pediatric Autoimmune Disease, Mesenchymal Stem Cells, Umbilical Cord Stem Cells, Regenerative Therapy.
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