A Rare Case of Mannitol-Induced Anaphylaxis During Treatment of Cerebral Edema

A Case Report | Open Access

Volume 2025 - 4 | Article ID 271 | http://dx.doi.org/10.51521/WJCRCI.2025.e42.415

A Rare Case of Mannitol-Induced Anaphylaxis During Treatment of Cerebral Edema

Academic Editor: John Bose

Received 2025-08-31
Revised 2025-10-14
Accepted 2025-10-21
Published 2025-10-22

Dr. Srishti Katiyar¹, Dr. Shruti S², Dr. Nishat Shaik³

¹Yenepoya University, University Road, Deralakatte, Mangaluru – 575018, Karnataka, India; Email: srishtiskat@gmail.com.

²Yenepoya University, University Road, Deralakatte, Mangaluru – 575018, Karnataka, India.

³Yenepoya University, University Road, Deralakatte, Mangaluru – 575018, Karnataka, India.

Corresponding author: Dr. Srishti Katiyar, Yenepoya University, University Road, Deralakatte, Mangaluru – 575018, Karnataka, India; Email: srishtiskat@gmail.com ORCID ID: https://orcid.org/0009-0002-8087-6178.

Citation: Dr. Srishti Katiyar, Dr. Shruti S, Dr. Nishat Shaik (2025) A Rare Case of Mannitol-Induced Anaphylaxis During Treatment of Cerebral Edema. World J Case Rep Clin Imag. 2025 October; 4(2),1-6.

Copyrights: © Dr. Srishti Katiyar, et al., 2025, This article is licensed under the Creative Commons Attribution-Non Commercial-4.0-International-License-(CCBY-NC) (https://worldjournalofcasereports.org/blogpage/copyright-policy). Usage and distribution for commercial purposes require written permission.

Abstract:

Mannitol, a commonly used osmotic diuretic for managing raised intracranial pressure and cerebral venous thrombosis, is generally safe but has been rarely associated with hypersensitivity reactions, including anaphylaxis. We report a 38-year-old male with cerebral venous thrombosis who developed sudden onset of generalized erythematous rash, itching, hypotension, and bradycardia immediately after intravenous administration of 20% mannitol. Prompt recognition and emergency management with adrenaline, corticosteroids, and antihistamines led to stabilization. This case highlights the importance of clinical vigilance for mannitol hypersensitivity, particularly in high-risk or atopic individuals, and underscores the need for awareness of rare but serious adverse reactions to this widely used agent. Further research is warranted to elucidate underlying immunopathological mechanisms and optimize patient safety.

Keywords: Anaphylaxis, Cerebral Edema, Thrombosis, Mannitol